PyPI86Excellenthealth index
aio-libs/yarlYet another URL library
Python★ 1,490↓ 592M/moJul 16, 2026
pypa/virtualenvVirtual Python Environment builder
Python★ 5,041↓ 506M/moJul 16, 2026
zeromq/pyzmqPyZMQ: Python bindings for zeromq
Python★ 4,157↓ 103M/moJul 22, 2026
cython/cythonThe most widely used Python to C compiler
Cython · Python★ 10.8KJul 17, 2026
rasterio/rasterioRasterio reads and writes geospatial raster datasets
Python · Cython★ 2,549Jul 21, 2026
aio-libs/propcacheFast property caching
Python★ 36Jul 16, 2026
scikit-build/scikit-buildImproved build system generator for CPython C, C++, Cython and Fortran extensions
Python · CMake★ 534↓ 1.2M/moJul 21, 2026
harfbuzz/uharfbuzzA HarfBuzz Python binding
Cython · Python★ 104Jul 21, 2026
PyPI · npm69Moderatehealth index
explosion/spaCy💫 Industrial-strength Natural Language Processing (NLP) in Python
Python · MDX · Cython★ 33.7K↓ 22M/moJul 17, 2026
crates.io · PyPI66Moderatehealth index
mabel-dev/opteryx-core⚙️ Opteryx Query Engine + Rugo File Driver
Python★ 4↓ 3,717/moJul 14, 2026
PyPI63Moderatehealth index
brentp/cyvcf2cython + htslib == fast VCF and BCF processing
Cython · Python★ 446Jul 21, 2026
PyPI61Moderatehealth index
mahmoudimus/ida-sigmakersigmaker is a zero-dependency IDA Pro 9.0+ cross-platform signature maker plugin with optional SIMD (e.g. AVX2/NEON/SSE2) speedups that works on MacOS/Linux/Windows. It allows configurable wildcard operand patterns, nibbles, and signature generation just by right clicking.
Python★ 204↓ 6,848/moJul 18, 2026
PyPI60Moderatehealth index
Toblerity/FionaFiona reads and writes geographic data files
Python · Cython★ 1,245Jul 21, 2026
PyPI59Moderatehealth index
explosion/preshed💥 Cython hash tables that assume keys are pre-hashed
Cython · Python · C★ 88↓ 20.6M/moJul 18, 2026
PyPI57Moderatehealth index
pythongssapi/python-gssapiA Python interface to RFC 2743/2744 (plus common extensions)
Python · Cython★ 115Jul 21, 2026
PyPI56Moderatehealth index
explosion/cython-blis💥 Fast matrix-multiplication as a self-contained Python library – no system dependencies!
C★ 238Jul 18, 2026
PyPI55Moderatehealth index
Kyle-J-Sun/SuperModelingFactoryProduction-grade Python toolkit for credit risk modeling — scorecards, LR, LightGBM/XGBoost, WOE/IV, PSI, KS, SHAP. Source-protected wheels via Cython.
Python★ 0Jul 18, 2026
PyPI55Moderatehealth index
explosion/cymem💥 Cython memory pool for RAII-style memory management
Cython · Python★ 461Jul 18, 2026
PyPI54Moderatehealth index
explosion/murmurhash💥 Cython bindings for MurmurHash2
C++ · C · Python★ 47↓ 20.6M/moJul 18, 2026
PyPI51Moderatehealth index
pytoolz/cytoolzCython implementation of Toolz: High performance functional utilities
Python · Cython★ 1,110Jul 18, 2026
Vizonex/WinloopAn Alternative library for uvloop compatability with windows
Cython · Python★ 228Jul 21, 2026
PyPI · npm45At riskhealth index
yuchi518/dybufdynamic buffer lib
C · Java★ 0↓ 4,090/moJul 15, 2026