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Python★ 10.5KAug 28, 2026
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Python★ 242Aug 22, 2026
PyPI · Go86Excellenthealth index
Python★ 8,263Aug 12, 2026
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Go · Shell★ 4Jul 20, 2026
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Go · Shell★ 2Jul 18, 2026
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Go · Shell★ 5Jul 18, 2026
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Python★ 290↓ 332K/moJul 21, 2026
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pysam-developers/pysamPysam is a Python package for reading, manipulating, and writing genomics data such as SAM/BAM/CRAM and VCF/BCF files. It's a lightweight wrapper of the HTSlib API, the same one that powers samtools, bcftools, and tabix.
Cython · Python★ 900↓ 1.2M/moJul 21, 2026
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python-openapi/openapi-spec-validatorOpenAPI Spec Validator is a CLI, pre-commit hook and python package that validates OpenAPI Specs against the OpenAPI 2.0 (aka Swagger), OpenAPI 3.0 and OpenAPI 3.1 specification.
Python★ 407↓ 40.6M/moAug 27, 2026
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pytroll/pyspectralPyspectral is a package to read and manipulate satellite sensor spectral responses and solar irradiance spectra
Python★ 81Jul 26, 2026
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Python★ 759↓ 923.4K/moSep 6, 2026
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Python★ 89Jul 18, 2026
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Python★ 570↓ 1.2M/moJul 21, 2026
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spec-first/connexionConnexion is a modern Python web framework that makes spec-first and api-first development easy.
Python★ 4,608Aug 12, 2026
PyPI · crates.io · npm86Excellenthealth index
Rust★ 77↓ 3,523/moAug 22, 2026
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Python★ 483↓ 9,853/moAug 22, 2026
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stephrobert/dsoxlabDevSecOps XL Labs — a domain-agnostic CLI framework to drive hands-on learning labs across multiple repositories
Python★ 55↓ 3,355/moJul 27, 2026
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stumpy-dev/stumpySTUMPY is a powerful and scalable Python library for modern time series analysis
Python★ 4,143Aug 13, 2026
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Python★ 2↓ 3,076/moSep 5, 2026
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theochem/gridPython library for numerical integration, interpolation, and differentiation on (molecular) grids.
Python★ 100Aug 15, 2026
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Python★ 77Jul 30, 2026
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Python★ 116Jul 17, 2026
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vaaraio/vaaraAccountable Autonomy: open-source evidence layer that gates every AI agent tool call against your policy and writes a hash-chained record an auditor verifies offline, without trusting you. Root-agnostic; binds to TPM 2.0 / SEV-SNP when present. Your environment, no SaaS, no telemetry. AGPL-3.0.
Python★ 11↓ 6,460/moAug 22, 2026
npm · Packagist · crates.io +186Excellenthealth index

xberg-io/tree-sitter-language-packComprehensive tree-sitter grammar compilation with polyglot bindings — Rust, Python, Node.js, Go, Java, Ruby, Elixir, PHP, C#, WASM, Dart, Kotlin-Android, Swift, Zig, and CLI. 371 languages.
Rust★ 462↓ 1,751/moAug 27, 2026
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Python★ 116↓ 265.4K/moSep 5, 2026
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Python★ 350Jul 18, 2026
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Python★ 1,025Aug 13, 2026
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Blackcat-Informatics/purrdfPurRDF — one RDF 1.2 engine, one behavior, every language: interned primitives, Turtle/TriG/N-Quads/RDF-XML/JSON-LD codecs, RDFC-1.0, SPARQL 1.1/1.2, SHACL Core, GTS graph transport, and Python/WebAssembly/C bindings.
Rust★ 15↓ 5,503/moJul 26, 2026
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Python★ 134↓ 2.4M/moAug 27, 2026
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Comfy-Org/ComfyUIThe most powerful and modular diffusion model GUI, api and backend with a graph/nodes interface.
Python★ 123.6KAug 4, 2026