haddocking/powerfitRigid body fitting of atomic strucures in cryo-electron microscopy density maps
Python★ 24↓ 514/moJul 17, 2026
hedypamungkas/koboi-agentSelf-hostable AI agents you can actually leave running — durable crash-resume, governed autonomy, seccomp sandbox, offline-replayable workflows, CI-native eval. Async-Python, YAML-config, multi-provider (OpenAI/Anthropic/Cloudflare), MIT.
Python★ 1↓ 4,014/moJul 19, 2026

httplib2/httplib2Small, fast HTTP client library for Python. Features persistent connections, cache, and Google App Engine support. Originally written by Joe Gregorio, now supported by community.
Python · HTML★ 509Aug 4, 2026
Python · C★ 465Jul 17, 2026
Jupyter Notebook★ 31Aug 4, 2026
janluke/cloupLibrary to build command line interfaces based on Click. It extends click with: option groups, constraints (e.g. mutually exclusive params), command aliases, help themes, "did you mean ...?" suggestions and more.
Python★ 132↓ 928.5K/moJul 21, 2026
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Python★ 1,573Jul 17, 2026
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Python★ 42↓ 58.6K/moJul 19, 2026

mbi/django-simple-captchaDjango Simple Captcha is an extremely simple, yet highly customizable Django application to add captcha images to any Django form.
Python★ 1,422Aug 13, 2026
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Python★ 3↓ 2,425/moSep 5, 2026
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C · Python★ 3,652↓ 63.1M/moAug 27, 2026

pyexcel/pyexcelSingle API for reading, manipulating and writing data in csv, ods, xls, xlsx and xlsm files
Python★ 1,293Aug 13, 2026
Python★ 2,188Jul 16, 2026
pypa/pyproject-hooksA low-level library for calling build-backends in `pyproject.toml`-based project
Python★ 128Jul 21, 2026
Python★ 335Aug 4, 2026

python-zk/kazooKazoo is a high-level Python library that makes it easier to use Apache Zookeeper.
Python★ 1,322Aug 13, 2026

pywbem/pywbemPywbem - A WBEM client and related utilities, written in pure Python.
Python★ 43↓ 16.9K/moAug 31, 2026
quantumlib/chromobiusOpen-source implementation of a Möbius decoder for color codes used in quantum error correction (QEC)
Python · C++★ 38↓ 18.3K/moJul 18, 2026
Python★ 9Jul 17, 2026
Python · Objective-C★ 798↓ 1.2M/moJul 18, 2026
Python★ 1↓ 30.9K/moAug 16, 2026
Python★ 0↓ 52.6K/moAug 18, 2026